cognitive dysfunction — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8390	Cefazolin		Others , Antibacterial , Antibiotic
	Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.		Others , Antibacterial , Antibiotic
T1780	Parecoxib	SC 69124,Vorth-P,Valus-P	COX
	Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.		COX
T6975	Sarcosine	Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine	Others , GlyT , Endogenous Metabolite
	Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.		Others , GlyT , Endogenous Metabolite
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T0953	Cefazolin sodium	Ancef,Cefazolin sodium salt,Sodium cephazolin,cephazolin sodium,cefazoline sodium,Sodium cefazolin	Others , Antibacterial , Antibiotic
	Cefazolin sodium (cephazolin sodium) salt binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cefazolin sodium salt is the sodium salt of cefazolin, a beta...		Others , Antibacterial , Antibiotic
T1406	Amantadine hydrochloride	1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor , Influenza Virus
	Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.		Dopamine Receptor , Influenza Virus
T27462	GSK-239512	GSK239512,GSK 239512	Histamine Receptor
	GSK-239512 is an antagonist of H3 receptor and can be used in studies about the treatment of cognitive dysfunction in neurodegenerative disorders.		Histamine Receptor
T62839	Dalzanemdor	SAGE-718	NMDAR , iGluR
	Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.		NMDAR , iGluR
T60835	SKF83959		Dopamine Receptor
	SKF83959, a benzazepine analog, is a selective and potent partial agonist of the dopamine D1 receptor with Ki values of 1.18, 7.56, 920, and 399 nM for rat D1, D5, D2, and D3 receptors, respectively.SKF83959 is a potent ...		Dopamine Receptor
T30922	CI-1002	PD-142676,UNII-7U374ZW3YB
	CI-1002 is a novel anticholinesterase and muscarinic antagonist that can be used to treat cognitive dysfunction in AD with fewer peripheral side effects.
T34751	Usmarapride free base	SUVN-D4010,SUVN-D 4010,SUVN-D-1208045,SUVN-1004028,SUVN D4010,SUVN-D1003019
	SUVN-D4010 is an effective, selective, brain penetrant, and orally active agonist of 5-HT4 receptor partially used to treat Alzheimer's disease and other dementia-related cognitive dysfunction.
T39677	MY33-3	MY33-3
	MY33-3 is a powerful and specific inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, demonstrating an IC50 value of approximately 0.1 μM. Moreover, MY33-3 exhibits inhibitory activity against PTP-1B with an IC...
T75300	Cefazolin sodium pentahydrate
	Cefazolin sodium pentahydrate, a first-generation cephalosporin antibiotic, is employed in diverse bacterial infection research [1] and exhibits an anti-inflammatory effect capable of attenuating post-operative cognitive...
T62442	MY33-3 hydrochloride
	MY33-3 hydrochloride is a potent and selective inhibitor of the protein tyrosine phosphatase RPTPβ/ζ (IC50~0.1 μM). MY33-3 hydrochloride inhibits PTP-1B (IC50~0.7 μM). MY33-3 hydrochloride reduces ethanol consumption and...
T33766	OAB-14	OAB 14,OAB14
	OAB-14 is a Bexarotene derivative that improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the e...
T80106	Z-Pro-Pro-aldehyde-dimethyl acetal		Prolyl Endopeptidase (PREP)
	Z-Pro-Pro-aldehyde-dimethyl acetal is a potent prolyl endopeptidase (PREP) inhibitor, effectively impeding the activity of this cytoplasmic serine endoprotease with an IC50 of 12 nM. Its significance is underscored by it...		Prolyl Endopeptidase (PREP)
T37013	(+/-)-PPCC oxalate
	Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors,...